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The Treatment of Acute Acetaminophen Poisoning

Rocky Mountain Poison and Drug Center, Denver General Hospital, Denver, CO 80204-4507

Barry H. Rumack, MD

Rocky Mountain Poison and Drug Center, Denver General Hospital, Denver, CO 80204-4507

Accidental or intentional overdose with acetaminophen is a relatively common occurrence. Few patients ingesting an overdose of acetaminophen will develop a fulminant clinical course resulting in death. Some are at risk for developing acetaminophen-induced hepatotoxicity unless properly treated with the prophylactic antidote N-acetylcysteine within the first 24 hours after ingestion. Intensive supportive care will allow an excellent prognosis for those patients developing hepatotoxicity or other, more rare, sequelae of acetaminophen poisoning.

Journal of Intensive Care Medicine, Vol. 1, No. 1, 29-32 (1986)
DOI: 10.1177/088506668600100106


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