This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Kinoshita, M. Articles by Mochizuki, H. Search for Related Content PubMed Articles by Kinoshita, M. Articles by Mochizuki, H. Social Bookmarking                         What's this?

Neutrophil-Related Inflammatory Mediators in Septic Acute Respiratory Distress Syndrome

Department of Surgery, National Defense Medical College Research Institute, Saitama, Japan, manabu{at}res.ndmc.ac.jp

Satoshi Ono, MD, PhD

Department of Surgery, National Defense Medical College Research Institute, Saitama, Japan

Hidetaka Mochizuki, MD, PhD

Department of Surgery, National Defense Medical College Research Institute, Saitama, Japan

To disclose the participation of neutrophils in septic acute respiratory distress syndrome (ARDS), characteristics of various inflammatory mediators were examined in septic patients. Forty-seven gram-negative septic patients were divided into ARDS (n = 23) and non-ARDS (n = 24) groups at the transferred point to the intensive care unit. The mediators were measured simultaneously at the transferred point, and then subsequently on days 1, 3, and 5. At the transferred point, the ARDS group showed significantly higher levels of interleukin-8 (IL-8), macrophage inflammatory peptide-1-alpha (MIP-1-), soluble intercellular adhesion molecule-1 (sICAM-1), and neutrophil elas-tase despite lower neutrophil counts compared to the non-ARDS group. The ARDS group sustained significantly higher levels of sICAM-1 until day 5 and neutrophil elas-tase until day 1 compare to the non-ARDS group. Furthermore, nonsurviving ARDS patients (n = 8) showed significantly higher levels of tumor necrosis factor-alpha, IL-6, IL-8, and IL-10 compared to surviving ARDS patients (n = 15) at the transferred point. In conclusion, neutrophil-related inflammatory mediators, IL-8, MIP-1-, sICAM-1, and neutrophil elastase, appear to possibly participate in septic ARDS. Cytokines might also play an important role in the mortality of such cases.

Key Words: acute respiratory distress syndrome • sepsis • neutrophil • cytokine • adhesion molecule • neutrophil elastase

Journal of Intensive Care Medicine, Vol. 17, No. 6, 308-316 (2002)
DOI: 10.1177/0885066602238033


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				P. E. Marik Pharmacologic Strategies for the Treatment of Acute Respiratory Distress Syndrome: The Horizon is Getting Closer J Intensive Care Med, November 1, 2002; 17(6): 326 - 328. [PDF]