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Intraoperative Administration of Nitric Oxide

The Departments of Child Health and Anesthesiology, The University of Missouri, Columbia.

Joseph D. Tobias, MD

The Departments of Child Health and Anesthesiology, The University of Missouri, Columbia. tobiasj{at}health.missouri.edu

Despite its therapeutic efficacy in various clinical scenarios in the intensive care unit setting, there are limited reports regarding the intraoperative applications of nitric oxide (NO). The authors present 2 pediatric patients to whom inhaled NO was administered intraoperatively. In one patient, NO was used to treat hypoxemia that developed after the institution of one-lung ventilation during thoracoscopic resection of a bronchiectatic section of lung. In the second patient, NO was used to alleviate pulmonary hypertension and cardiovascular dysfunction with pulmonary artery cross-clamping for placement of a modified Blalock-Taussig shunt. The potential intraoperative applications and techniques for the intraoperative delivery of NO are presented.

Key Words: nitric oxide • one-lung ventilation • pulmonary hypertension • hypoxemia

Journal of Intensive Care Medicine, Vol. 18, No. 3, 146-149 (2003)
DOI: 10.1177/0885066603251615


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