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Hypogammaglobulinemia in Pediatric ICU Patients

Departments of Child Health and Anesthesiology, Division of Pediatric Critical Care/Pediatric Anesthesiology, University of Missouri, Columbia, Missouri

Daniel Bytnar, BS

Departments of Child Health and Anesthesiology, Division of Pediatric Critical Care/Pediatric Anesthesiology, University of Missouri, Columbia, Missouri

John W. Berkenbosch, MD

Departments of Child Health and Anesthesiology, Division of Pediatric Critical Care/Pediatric Anesthesiology, University of Missouri, Columbia, Missouri

Joseph D. Tobias, MD

Departments of Child Health and Anesthesiology, Division of Pediatric Critical Care/Pediatric Anesthesiology, University of Missouri, Columbia, Missouri, Tobiasj{at}health.missouri.edu

The authors retrospectively review their experience with low immunoglobulin G (IgG) levels in a pediatric ICU population over a 12-month period. The total IgG level was below the normal for age in 14 of the 20 patients. The 14 patients with a low IgG level were younger and weighed less when compared with the 6 patients who had a normal IgG level. There was no difference in the risk of mortality between the 2 groups. In the 14 patients with an IgG level less than normal for age, the IgG level was 33% to 99% of normal, with 4 patients having a level less than 50% of normal for their age. Prospective trials are needed to determine the incidence of this problem, its impact on survival, and the appropriate therapy in the pediatric ICU population.

Key Words: hypogammaglobulinemia • pediatrics • intensive care

Journal of Intensive Care Medicine, Vol. 18, No. 5, 261-264 (2003)
DOI: 10.1177/0885066603255905


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