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Journal of Intensive Care Medicine, Vol. 19, No. 6, 345-348 (2004)
DOI: 10.1177/0885066604269771

Creutzfeldt-Jakob Disease Presenting as Refractory Nonconvulsive Status Epilepticus

Janet M. Shapiro, MD

Division of Pulmonary–Critical Care Medicine, St. Luke’s Hospital MU 316, 1111 Amsterdam Avenue, New York, NY 10025Jshapiro{at}chpnet.org

Adil Shujaat, MD

Jill Wang, MD

Xiaowei Chen, MD

Departments of Medicine and Pathology, St. Luke’s-Roosevelt Hospital Center, New York, NY

A 70-year-old woman was admitted to the intensive care unit with refractory nonconvulsive status epilepticus. Extensive evaluation including neuroimaging and cerebrospinal fluid examination was unrevealing. Brain biopsy revealed spongiosis, and prion disease was confirmed by immunostaining, providing the diagnosis of Creutzfeldt-Jakob disease.

Key Words: Creutzfeldt-Jakob disease • status epilepticus • brain biopsy • prion


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