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Journal of Intensive Care Medicine
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Refeeding Syndrome and Hypophosphatemia

Mark A. Marinella, MD, FACP, FACN, CNSP

Wright State University School of Medicine, Dayton, OH, Mmarinella{at}pol.net

Hypophosphatemia is a potentially life-threatening complication of reinstating nutrition in a malnourished patient. Refeeding syndrome is a term that refers to various metabolic abnormalities that may complicate carbohydrate administration in subnourished patient populations. Hypophosphatemia is the most well-known, and perhaps most significant, element of the refeeding syndrome and may result in sudden death, rhabdomyolysis, red cell dysfunction, and respiratory insufficiency. This review briefly examines refeeding-induced hypophosphatemia in the hospitalized patient in hopes of making clinicians more aware of this common, but often overlooked, potentially dangerous problem.

Key Words: refeeding syndrome • hypophosphatemia • electrolytes

Journal of Intensive Care Medicine, Vol. 20, No. 3, 155-159 (2005)
DOI: 10.1177/0885066605275326
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