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Fatal Rapidly Progressive Interstitial Pneumonitis Associated With Amyopathic Dermatomyositis and CD8 T Lymphocytes

First Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan, tyokoyama{at}cogeco.ca

Teruo Sakamoto, MD

Emergency and Critical Care Medical Center, Kurume University School of Medicine, Kurume, Japan

Norihiko Shida, MD

Emergency and Critical Care Medical Center, Kurume University School of Medicine, Kurume, Japan

Masaharu Kinoshita, MD

First Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan

Yoshifumi Kunou, MD

Emergency and Critical Care Medical Center, Kurume University School of Medicine, Kurume, Japan

Ritsuko Karukaya, MD

Emergency and Critical Care Medical Center, Kurume University School of Medicine, Kurume, Japan

Manabu Takamatsu, MD

Emergency and Critical Care Medical Center, Kurume University School of Medicine, Kurume, Japan

Hisamichi Aizawa, MD

First Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan

A patient with amyopathic dermatomyositis associated with fatal rapidly progressive interstitial pneumonitis resistant to therapy is described. Pathologic examination of a transbronchial lung biopsy specimen showed diffuse alveolar damage and nonspecific interstitial pneumonia-organizing pneumonia-like findings. Bronchoalveolar lavage fluid contained many CD8+ lymphocytes, considered to be cytotoxic T cells. Analysis of bronchoalveolar lavage fluid in this case may provide prognostically and pathogenetically important information.

Key Words: amyopathic dermatomyositis • interstitial pneumonitis • bronchoalveolar lavage • cytotoxic T cell

Journal of Intensive Care Medicine, Vol. 20, No. 3, 160-163 (2005)
DOI: 10.1177/0885066605275391


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