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Journal of Intensive Care Medicine, Vol. 21, No. 6, 369-371 (2006)
DOI: 10.1177/0885066606293384

Use of Molecular Adsorbent Recirculating System in Acute Liver Failure Attributable to Dengue Hemorrhagic Fever

Alvin Penafiel, MD, FPCP

Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore, agp1502{at}aim.com

Anantham Devanand, MBBS, MRCP

Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore

Han Khim Tan, MBBS, MRCP

Department of Renal Medicine, Singapore General Hospital, Singapore

Philip Eng, FCCP, FACP

Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore

Fulminant liver failure is an uncommon but life-threatening complication of severe dengue infection. Molecular adsorbent recirculating system (MARS), which reverses hepatic encephalopathy, is an emerging important element in the armamentarium of organ support in the intensive care unit in patients suffering from acute liver failure. We report an intensive care unit case of fulminant liver failure secondary to dengue hemorrhagic fever, which was supported with MARS. MARS led to rapid reversal of biochemical profile and encephalopathy, resulting in early extubation and intensive care unit discharge.

Key Words: molecular adsorbent recirculating system • acute liver failure • liver dialysis • dengue


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