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Analytic Reviews : Organ Procurement and Brain Death in Trauma Patients

From the Department of Surgery, University of California Medical Center, San Diego, 225 Dickinson St, San Diego, CA 92103

The success rates and effectiveness of transplantation programs continue to increase, as does the need for cadaveric organs. Increasing organ procurement is a worthwhile goal that can be fully justified on economic, humanistic, and ethical bases. Although a great deal of progress has been made in terms of public and political awareness of organ procurement problems, additional changes and further education will be necessary before the number of cadaveric organs that are needlessly wasted can be reduced.

Management of patients with unsurvivable head in juries or patients who are candidates for organ donation is a complex task involving critical care management, the declaration of brain death, and the identification of, and request for, organ donation from next of kin. This process involves the coordinated efforts of neurosur geons, critical care specialists, social workers, and the transplant team coordinators in organ procurement pro grams. Patients are best managed in tertiary centers that have staffs with the expertise and interest in performing these tasks. The time to cardiac death in brain-dead pa tients is frequently short and is hastened by the develop ment of rapidly progressive derangements in gas ex change, fluid and electrolyte homeostasis, temperature regulation, coagulation, and cardiovascular function. Premature death under these circumstances continues to be a major reason for organ-procurement failure. Ag gressive monitoring and treatment of the multiple med ical problems encountered, however, may reduce the number of patients who die prematurely and thus in crease organ procurement rates.

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