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Pharmacological Approach to the Prevention and Treatment of Stress Ulcers

Department of Pharmacy and Pharmaceutics and the Department of Internal Medicine, Medical College of Virginia, Richmond, VA

The mortality associated with bleeding stress ulcers in patients in intensive care units exceeds 50%. Iden tification of patients at risk and use of early and effec tive prophylaxis are necessary in the management of patients in intensive care units. The use of antacids is inconvenient, expensive, and associated with electro lyte disturbances and erratic pH control. H₂-receptor antagonists are the preferred agents for stress ulcer pro phylaxis because of their proven efficacy, safety, and ease of administration. Adjunct therapy with cyto protective agents may be useful in patients with com promised mucosal defences.

Journal of Intensive Care Medicine, Vol. 5, No. 1S, S10-S16 (1990)
DOI: 10.1177/088506669000500103


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