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Journal of Intensive Care Medicine
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Prevention and Management of Metabolic Alkalosis

Beth S. Friedman

Department of Pediatric Allergy and Immunology, National Institutes of Health, Bethesda, MD

Philip D. Lumb

Department of Anesthesiology, Albany Medical College, Albany, NY

Metabolic alkalosis is the most common acid-base disor der seen in hospitalized patients. There are three types of metabolic alkalosis: chloride responsive, chloride re sistant, and exogenous administration of alkali. Chlo ride-responsive alkalosis is the most common.

Metabolic alkalosis can result in numerous metabolic abnormalities as well as cardiovascular and neurological dysfunction. Histamine H2-receptor antagonists are im portant in the prevention, control, and acute treatment of chloride-responsive metabolic alkalosis. In most pa tients chloride-responsive metabolic alkalosis can be managed successfully with fluid therapy and H 2-recep tor antagonists or a carbonic anhydrase inhibitor (for example, acetazolamide).

Journal of Intensive Care Medicine, Vol. 5, No. 1S, S22-S27 (1990)
DOI: 10.1177/088506669000500105
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