|
Sign In to gain access to subscriptions and/or personal tools.
|
Journal of Intensive Care Medicine, Vol. 21, No. 6,
364-368 (2006)
DOI: 10.1177/0885066606293365
© 2006 SAGE Publications
Two Cases of Tetanus?
Janneke Horn, MD, PhD
Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, the Netherlands, j.horn{at}amc.uva.nl
Margreeth B. Vroom, MD, PhD
Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, the Netherlands
Marina A. J. Tijssen, MD, PhD
Department of Neurology, Academic Medical Center, University of Amsterdam, the Netherlands
Marcus J. Schultz, MD, PhD
Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, the Netherlands
Tetanus is a rare infectious disease in Western countries that leads to diagnostic difficulties. Several diseases may mimic tetanus, and diagnostic considerations can at times be difficult, especially in critically ill patients, who need prompt treatment. Two patients are presented who were diagnosed with and treated for tetanus. However, the course of these patients diseases strongly suggested that the diagnoses were incorrect. The article includes reflections on these 2 difficult diagnostic cases. These 2 cases illustrate the importance of proposing alternative diagnoses in suspected tetanus in Western countries. This may prevent loss of valuable time and prevent a delay of possibly effective therapy.
Key Words: tetanus encephalomyelitis with rigidity and myoclonus limbic encephalitis
References
- Farrar J, Yen L, Cook T, et al. Tetanus. J Neurol Neurosurg Psychiatry. 2000;69: 292-301.[Free Full Text]
- Montecucco C, Schiavo G. Mechanism of action of tetanus and botulinum neurotoxins. Mol Microbiol. 1994;13: 1-8.[Medline]
[Order article via Infotrieve]
- Ernst ME, Klepser ME, Fouts M, Marangos MN. Tetanus: pathophysiology and management. Ann Pharmacother. 1997;1507-1513.
- Ahmadsyah I, Salim A. Treatment of tetanus: an open study to compare the efficacy of procaine penicillin and metronidazole. BMJ. 1985;291: 650-650.
- Pascual FB, McGinley EL, Zanardi LR, Cortese MM, Murphy TV. Tetanus surveillanceUnited States, 1998-2000. MMWR Surveill Summ. 2003;52: 1-8.[Medline]
[Order article via Infotrieve]
- Schon F, ODowd L, White J. Tetanus: delay in diagnosis in England and Wales. J Neurol Neurosurg Psychiatry. 1994;57: 1006-1007.[Abstract]
- Brown P, Marsden CD. The stiff man and stiff man plus syndromes. J Neurol. 1999;246: 648-652.[CrossRef][Medline]
[Order article via Infotrieve]
- Meinck HM, Thompson PD. Stiff man syndrome and related conditions. Mov Disord. 2002;17: 853-866.[CrossRef][Medline]
[Order article via Infotrieve]
- Barker RA, Revesz T, Thom M, Marsden CD, Brown P. Review of 23 patients affected by the stiff man syndrome: clinical subdivision into stiff trunk (man) syndrome, stiff limb syndrome, and progressive encephalomyelitis with rigidity. J Neurol Neurosurg Psychiatry. 1998;65: 633-640.[Abstract/Free Full Text]
- Bateman DE, Weller KO, Kennedy P. Stiffman syndrome: a rare paraneoplastic disorder? J Neurol Neurosurg Psychiatry. 1990;53: 695-696.[Abstract]
- Gultekin SH, Rosenfeld MR, Voltz R, Eichen J, Posner JB, Dalmau J. Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour associations in 50 patients. Brain. 2000;123: 1481-1494.[Abstract/Free Full Text]
- Graus F, Keime-Guibert F, Rene R, et al. Anti-Hu-associated paraneoplastic encephalomyelitis: analysis of 200 patients. Brain. 2001;124: 1138-1148.[Abstract/Free Full Text]
- Thieben MJ, Lennon VA, Boeve BF, Aksamit AJ, Keegan M, Vernino S. Potentially reversible autoimmune limbic encephalitis with neuronal potassium channel antibody. Neurology. 2004;62: 1177-1182.[Abstract/Free Full Text]
- Vincent A, Buckley C, Schott JM, et al. Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis. Brain. 2004;127: 701-712.[Abstract/Free Full Text]

CiteULike Connotea Del.icio.us Digg Reddit Technorati What's this?
|